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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727ac33cec9beeef5336527f58b94e1fb7bffa5fad7cb565d803df3c2b7519c8' 
  AND token = 'po64y+dVGZNgyfphGE+ef67zyvViApVHt/pzV1ivaJk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}