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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e292906c4a2e09aa27d94ce795626462a91b9f259a1faac4136c27c199e09a7' 
  AND token = 'RExl1q0TIxrviMf9yE91BaGVw1NCpwcc4J35AYYUZwQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}